Objective:Recent improvements in life expectancy globally require intensified focus on noncommunicable diseases and age-related conditions. The purpose of this article is to inform the development of age-specific prevention guidelines for adults aged 50 and above, which are currently lacking.Data Source:PubMed, Cochrane database, and Google Scholar and explicit outreach to experts in the field.Study Inclusion and Exclusion Criteria:Meta-analyses, intervention-based, and prospective cohort studies that reported all-cause mortality, disease-specific mortality, or morbidity in adults were included.Data Extraction:A systematic review was undertaken in 2015 using search terms of a combination of and “intervention,” “mortality,” “reduction,” “improvement,” “death,” and “morbidity.”Data Synthesis:Interventions were categorized according to the Center for Evidence-Based Medicine Level of Evidence framework …