Purpose: Physical inactivity is associated with multiple health conditions including musculoskeletal disorders which have economic consequences to employers and wider society. Physically active employees have lower levels of absenteeism or presenteeism, greater productivity in the workplace, and are less likely to suffer from stress, depression and disabling musculoskeletal pain. Workplace sickness alone is estimated to cost the economy in England£ 5.5 bn a year. The purpose of this systematic review was to investigate which interventions work to increase physical activity and reduce sedentary behaviour in a workplace context?Methods: The authors systematically searched six electronic databases (Medline, Embase, AMED, The Cochrane Library, The King’s Fund and DH-Data) for eligible studies.