The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum …

Through genome-wide association studies, we have recently identified seven novel loci that confer a substantial increase in risk for coronary artery disease (CAD). Elucidating the mechanisms by which these loci affect CAD risk could have important clinical utility. Here, we investigated whether these loci act through mechanisms involving traditional cardiovascular risk factors. We genotyped 2,037 adult individuals from 520 nuclear families characterised for body mass index, waist-hip ratio, 24-h ambulatory blood pressure, total cholesterol, high-density lipoprotein cholesterol and glucose for the lead single nucleotide polymorphisms (SNPs) in the seven CAD-associated loci. SNP rs599839, representing the locus in the vicinity of the PSRC1 and CELSR2 genes on chromosome 1p13.3, showed a strong association with total cholesterol. The CAD-associated risk allele A of rs599839 (allele frequency 0.78 …

NJ Samani, PS Braund, J Erdmann, A Götz… – Journal of molecular medicine, 2008
Publication date
Journal of molecular medicine
Total citations
Cited by 108

Table of Contents

Newsletter signup

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus,  luctus nec ullamcorper mattis, pulvinar dapibus leo.

We respect your privacy and
will never share your details